Recent advances in wearable cortisol sensors

The pervasive stress in modern life makes the timely prevention and treatment of numerous stress-related physiological and psychological disorders a critical imperative. Thanks to recent significant advancements, the rapid, accurate, and on-site measurement of cortisol—a key stress biomarker—using miniaturized digital devices is now within reach.

Aptamer-regulated biosensors (aptasensors) hold particular promise in the fields of diagnostics and healthcare monitoring. They are expected to be used for the quantitative monitoring of cortisol levels in various biological matrices, including sweat, saliva, urine, cerebrospinal fluid, and serum.

This in-depth research review, therefore, examines the remarkable achievements in aptasensor strategies for detecting cortisol, especially through the synergistic action of various 2D/3D nanostructured materials, enzymatic amplification components, and antibody materials.

It offers a comprehensive perspective on realizing lab-on-a-chip aptasensor arrays as future user-friendly, skin-patchable electronic devices. These devices could be used anywhere to quantify and monitor cortisol levels in real time.

Reference：

https://pubmed.ncbi.nlm.nih.gov/37541008/