Exosome Purification Kit

Genimer™ Exosome Purification Magnetic Bead, this kit targets CD63 and CD9 to deliver high-purity exosome isolation at about 80% for critical downstream applications.

This Genimer™ magnetic bead affinity capture kit is a highly efficient separation solution specifically designed for exosome research. Addressing the pain points commonly encountered by academia and industry in exosome extraction, such as unstable recovery rates and loss of sample activity, Chipone Biotech utilizes its proprietary nucleic acid aptamer technology to replace traditional bulky and unstable antibodies, setting a new standard for exosome separation and purification.

This kit precisely captures the most common protein markers on the surface of exosomes— CD63, CD9, or CD81 . Chemically synthesized nucleic acid aptamers exhibit extremely strong affinity for the target markers. The key technology lies in its gentle elution mechanism, which separates the exosomes without damaging the membrane structure, ensuring the recovered samples possess extremely high biological activity and perfectly aligning with subsequent NanoFCM analysis, proteomics, or functional cell experiments.

Five core features of the product:

⚡ 2.5 times higher recovery rate: Thanks to the high affinity of nucleic acid aptamers, experiments have shown that its capture efficiency is significantly better than that of traditional commercial magnetic bead antibodies, maximizing the recovery of valuable clinical samples.
🧬 Maintain 98% structural integrity: A gentle, competitive elution method is used to avoid damage to exosomes from strong acids or high-salt environments, thus fully preserving their natural conformation and functional activity.
🚫 0% Antibody Protein Contamination: The all-chemical synthesis technology ensures no foreign protein residue, effectively eliminating background noise and making downstream Western blotting or sequencing analysis more accurate.
🌡️ Excellent batch stability: Nucleic acid aptamers have excellent acid, alkali and heat stability and achieve 0% batch-to-batch variation, ensuring a high degree of reproducibility of experimental data.
🎯 Precise Subgroup Sorting: Provides proprietary adaptors targeting three markers: CD63, CD9, and CD81. These can be used alone or in combination to meet the research needs of specific exosome subgroups.

Item/Feature	Genimer™ CD9/CD63 Exosome Purification Kit	CD9/CD63 Antibody Capture Kit	Size Exclusion Chromatography
Combination mechanism and Specificity	CD9/CD63 Genimer™ Probe Specificity identification CD9/CD63	CD9/CD63 antibody probe Specificity identification CD9/CD63	Separate according to size Nonspecificity
Purity	High (focusing only on specific exosomes)	High (focusing only on specific exosomes)	Low (separation based on particle size)
Washing method	gentle	acidic solution	gentle
Exosome integrity	Maintaining a complete structure	Structural damage	Maintaining a complete structure
Recovery rate	High-density bonding sites	(Limited by spatial steric hindrance)	Medium (subject to size limitations)
Further processing is needed.	No need	No need	Further purification or concentration is needed.
Product differences	It can maintain the integrity of exosomes. Low cost and high stability	Exosome structure damage, high cost, Batch variation	It can maintain the integrity of exosomes. Low cost, but low purity.

Genimer® can significantly increase the purity of CD63+ by up to 7 times.

CD63 Purity -10% TRADITIONAL TFF

CD63 Purity - 68.79% GENIMER™ PLATFORM